Abstract:
Endometriosis is characterized by growth of uterine material outside the uterus,
excessive menstrual discharge, pelvic and lower back pain, dysmenorrhea,
dyspareunia and infertility. It has been reported to occur in 10 to 15% of women in
reproductive ages. Many theories have been advanced to explain its origin but
retrograde menstruation proposed by Sampson in 1920s proposing that eutopic
endometrial material travels to peritoneal cavity through fallopian tubes is
supported by multiple lines of scientific evidence and most widely accepted. The
disease results from a complex interplay of TGF- bettas, matrix metallo-proteinases
and a host of other reactions. The disease is managed by medical interventions but
surgery remains the gold standard for treatment. Cost of management is prohibitive
and includes ambulatory charges, hospitalization, cost of medication, time-off work
and psychosocial impacts associated with infertility. That the disease affects women
who already bear huge responsibilities at family level elevate the psychosocial
impacts to unbearable levels. There is need to form multi-institutional basic science
and clinical research teams to advance knowledge on diagnosis and management,
share data, and use research outcomes to advance awareness, advocacy and policy
changes to accommodate management of endometriosis as priority healthcare need
requiring deliberate national budgetary support.
