Mushroom Polysaccharide Extracts Delay Progression of Carcinogenesis in Mice

Abstract

Hepatocellular carcinoma results when cancerous cells are localized in the liver. It is distributed globally with high prevalence in sub-Saharan African, southern Asia, China and Japan. Diagnosis is experimental and in many cases inaccurate due to unreliability of markers. Prognosis is poor and the cost of treatment prohibitive. Conventional radiation and chemotherapy lead to loss of hair, fertility and general weakening of the body's immune system increasing a patient's risk to infection. These observations underscore the need for improved, or additional methods of cancer diagnosis and manage­ment. We investigated the effect of polysaccharide rich Pleurotus pulmonarius fruit body extracts on progres­sion of chemically induced hepatocellular carcinoma in CBA mice. Addition of Pleurotus pulmonarius extracts in diet delayed progression of carcinogenesis suggest­ ing that these extracts may be useful as adjuvants to conventional cancer therapies.