Abstract:
Introduction: Bisphenol A is a synthetic compound widely used in the production of polycarbonate plastics and epoxy
resins worldwide. As an environmental toxin, it has been reported in plastic equipment and utensils, water bottles
and bottle tops, water supply pipes and epoxy resins that coat most of the metal food cans. It is a known endocrinedisrupting chemical and has been progressively replaced by its derivatives including bisphenol S, bisphenol F, bisphenol
E, bisphenol AF, bisphenol B and tetramethyl bisphenol F. Bisphenol A and its analogues can bind to estrogen receptors
and trigger multiple cellular responses at the organism level.
Methods: A comprehensive literature review was done utilising electronic databases of PubMed, Google Scholar,
Hinari, Connected papers and Science Direct from 1991 onwards. The articles were only included if they reported
original relevant research and were limited to articles written in English.
Results: Animal models, including non-human primates, have been used to study their effects on the endocrine system.
Its endocrine disruption activity is reported to be the most studied effect in reproductive biology indicating that it may
potentially cause endometriosis in females. Though non-human primates are closely related to humans, limited data
exists on their associations between Bisphenol A exposure and its analogues and the pathophysiology of endometriosis.
Conclusion: Given the current multifaceted knowledge/theory on endometriosis etiology, there is a strong necessity
to conduct further biomedical research that utilises non-human primates to study the link between endocrine-disrupting
chemicals and its effects on endometriosis
